Уважаемая Анна,
Фрагмент недавнего обзора по терапии PAD (PVD), которыи показывает, что назначенный статин может быть влиять на перемежающую хромоту/дистанцию ходьбы (кстати здесь и в другом обзоре по ссылке трентал замалчивается/не рекомендуется, несмотря на одобрение FDA), цилостазол неплох, но по-моему недоступен в России и не рекомендуется при ХСН.
Exercise. In patients with stable intermittent claudication, exercise significantly improves maximal walking time and overall walking ability.41 Exercise is more effective than angioplasty for improving walking time and is also more effective than antiplatelet therapy, but it does not differ significantly from surgical treatment.42 The optimal exercise program for improving distances walked without claudication pain in patients with PAD involves intermittent walking to near-maximal pain over a period of at least 6 months.42 The mechanism by which exercise improves leg symptoms is uncertain, but it does not appear to operate through improvement of the ABI or growth of collateral vessels.43
Statin Drugs. In the randomized Scandinavian Simvastatin Survival Study (4S), simvastatin (20 to 40 mg/d) significantly reduced the incidence of new intermittent claudication from 3.6% (placebo) to 2.3% (simvastatin) over a median period of 5.4 years in 4444 patients with prior MI or angina pectoris (relative risk reduction [RRR], 0.62%; 95% CI, 0.44%-0.88%).44 Both simvastatin and atorvastatin also improve pain-free walking time.45-46 Observational data suggest that it is the non–cholesterol-lowering properties of statins that favorably influence leg function in patients with PAD.47-48
Blood Pressure–Lowering Drugs. Contrary to prior belief, beta-adrenergic antagonist drugs do not worsen intermittent claudication in patients with PAD but, if indicated, should be used with caution in severely affected patients.49 The combination of atenolol and nifedipine marginally reduces maximal treadmill walking distance,50 while angiotensin-converting enzyme inhibitors (captopril, perindopril) may improve walking distances.51-52
Cilostazol. Cilostazol is an inhibitor of phosphodiesterase type 3 and thereby inhibits platelet aggregation and causes vasodilation. A meta-analysis of 8 RCTs involving 2702 patients demonstrated that cilostazol improved maximum walking distance and pain-free walking distance.53 Although cilostazol has not been associated with the increase in cardiac mortality seen with other phosphodiesterase inhibitors such as milrinone (which was developed for the treatment of heart failure), it remains contraindicated in patients with PAD who have coexistent cardiac failure.
Other Treatments. Ticlopidine54 and ginkgo biloba special extract (Egb 761)55-56 significantly increase pain-free walking distance. Numerous other therapies, such as naftidrofuryl, pentoxifylline, garlic, testosterone, levocarnitine, propionyl-L-carnitine, and chelation therapy have been evaluated in RCTs but have not been shown to be effective or are less effective than established treatments.57-60 A variety of strategies to stimulate new collateral channels in peripheral ischemia, such as the use of growth factors and autologous bone marrow cells, are currently being evaluated.61-62
Management of Patients With Peripheral Arterial Disease Who Have Diabetes
Target Levels of Risk Factors in Patients With Diabetes
Blood pressure <130/80 mm Hg
Low-density lipoprotein cholesterol level <2.6 mmol/L (100 mg/dL)
Triglycerides level <1.7 mmol/L (150 mg/dL)
High-density lipoprotein cholesterol >1.1 mmol/L (40 mg/dL)
Glycosylated hemoglobin level <7%
Из JAMA. 2006 Feb 1;295(5):547-53.
Medical treatment of peripheral arterial disease.
Hankey GJ, Norman PE, Eikelboom JW
Полный текст бесплатен и доступен здесь после регистрации
wEffective Study Formula Guarantee Effectivestudyformula I Effective Study Formula Effective Study Formula Szh Search Label Milkfats Effective Study Formula Хирургическое лечение ИБС [Архив] - Дискуссионный Клуб Русского Медицинского Сервераg Study Effective Study Formula Triangle Trigonometry
yEffective Study Formula Guarantee Effectivestudyformula I Effective Study Formula Effective Study Formula Szh Search Label Milkfats Effective Study Formula Хирургическое лечение ИБС [Архив] - Дискуссионный Клуб Русского Медицинского Сервераo z z Effective Study Formula Effective Study Formula Effective Study Formula